Autor(es)

Leandro G Radusky and Syed Shah Hassan and Esteban Lanzarotti and Sandeep Tiwari and Syed Babar Jamal and Javed Ali and Amjad Ali and Rafaela Salgado Ferreira and Debmalya Barh and Artur Silva and Adrián G Turjanski and Vasco AC Azevedo

URL Pública

Abstract

The bacterium Corynebacterium pseudotuberculosis (Cp) causes caseous lymphadenitis (CLA), mastitis, ulcerative lymphangitis, and oedema in a number of hosts, comprising ruminants, thereby intimidating economic and dairy industries worldwide. So far there is no effective drug or vaccine available against Cp. Previously, a pan-genomic analysis was performed for both biovar equi and biovar ovis and a Pathogenicity Islands (PAIS) analysis within the strains highlighted a large set of proteins that could be relevant therapeutic targets for controlling the onset of CLA. In the present work, a structural druggability analysis pipeline was accomplished along 15 previously sequenced Cp strains from both biovar equi and biovar ovis.We computed the whole modelome of a reference strain Cp1002 (NCBI Accession …