Identification of novel molecular determinants of co-receptor usage in HIV-1 subtype F V3 envelope sequences
2020, Scientific Reports 10 (1), 12583, 2020Citas: 1
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Autor(es)
Maximiliano Distefano and Esteban Lanzarotti and María Florencia Fernández and Andrea Mangano and Marcelo Martí and Paula Aulicino
Abstract
HIV-1 determinants of coreceptor usage within the gp120 V3 loop have been broadly studied over the past years. This information has led to the development of state-of the-art bioinformatic tools that are useful to predict co-receptor usage based on the V3 loop sequence mainly of subtypes B, C and A. However, these methods show a poor performance for subtype F V3 loops, which are found in an increasing number of HIV-1 strains worldwide. In the present work we investigated determinants of viral tropisms in the understudied subtype F by looking at genotypic and structural information of coreceptor:V3 loop interactions in a novel group of 40 subtype F V3 loops obtained from HIV-1 strains phenotypically characterized either as syncytium inducing or non-syncytium inducing by the MT-2 assay. We provide novel information about estimated interactions energies between a set of V3 loops with known tropism in …