Target-Pathogen: a structural bioinformatic approach to prioritize drug targets in pathogens
2018, Nucleic acids research 46 (D1), D413-D418, 2018Citas: 57
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Autor(es)
Ezequiel J Sosa and Germán Burguener and Esteban Lanzarotti and Lucas Defelipe and Leandro Radusky and Agustín M Pardo and Marcelo Marti and Adrián G Turjanski and Darío Fernández Do Porto
Abstract
Available genomic data for pathogens has created new opportunities for drug discovery and development to fight them, including new resistant and multiresistant strains. In particular structural data must be integrated with both, gene information and experimental results. In this sense, there is a lack of an online resource that allows genome wide-based data consolidation from diverse sources together with thorough bioinformatic analysis that allows easy filtering and scoring for fast target selection for drug discovery. Here, we present Target-Pathogen database (http://target.sbg.qb.fcen.uba.ar/patho), designed and developed as an online resource that allows the integration and weighting of protein information such as: function, metabolic role, off-targeting, structural properties including druggability, essentiality and omic experiments, to facilitate the identification and prioritization of candidate drug targets in …
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