Autor(es)

Pablo Ivan Pereira Ramos and Darío Fernández Do Porto and Esteban Lanzarotti and Ezequiel J Sosa and Germán Burguener and Agustín M Pardo and Cecilia C Klein and Marie-France Sagot and Ana Tereza R De Vasconcelos and Ana Cristina Gales and Marcelo Marti and Adrián G Turjanski and Marisa F Nicolás

URL Pública

Abstract

Klebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can cause life-threatening infections. It has been found as the culprit of many infection outbreaks in hospital environments, being particularly aggressive towards newborns and adults under intensive care. Many Kp strains produce extended-spectrum β-lactamases, enzymes that promote resistance against antibiotics used to fight these infections. The presence of other resistance determinants leading to multidrug-resistance also limit therapeutic options, and the use of ‘last-resort’ drugs, such as polymyxins, is not uncommon. The global emergence and spread of resistant strains underline the need for novel antimicrobials against Kp and related bacterial pathogens. To tackle this great challenge, we generated multiple layers of ‘omics’ data related to Kp and prioritized proteins that could serve as attractive targets for antimicrobial …